When all patients with CRC who had universal screening were used as the denominator, 58 LS cases (diagnostic yield, 1.49% ) were identified in patients with CRC diagnosed at or before age 70 years, 60 LS cases (diagnostic yield, 1.54% ) were identified in those with CRC diagnosed at or before age 75 years, and 62 LS cases (diagnostic yield, 1.59% ) were identified in those with CRC diagnosed at or before age 80 years. Sixty-three LS cases (diagnostic yield, 1.62%) were identified by universal screening, with only 5 (7.9%) detected after age 70 years and 1 (1.6%) detected after age 80 years. To compare the performance of age-restricted and universal LS screening using reflex mismatch repair (MMR) immunohistochemistry (IHC) of CRC tumors.Ī large, diverse, community-based health care system.ģ891 persons with newly diagnosed CRC who had LS screening between 20.ĭiagnostic yield of different LS screening strategies. However, the efficiency of universal LS screening in elderly populations has not been well studied. Guidelines recommend screening all patients with newly diagnosed colorectal cancer (CRC) for Lynch syndrome (LS).
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